Yi Sun Lab

Lei W^#, Liu H^#, Deng W^#, Chen W^#, Liang Y, Gao W, Yuan X, Guo S, Li P, Wang J, Tong X*, Sun Y E*, Liang A*, Qian W*. Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory/relapsed large B cell lymphoma: a phase 1 trial, Nature Cancer, 2025, 6(1):786–800.

2.Yan Y^#, Sun D^#, Hu J^#, Chen Y^#, Sun L, Yu H, Xiong Y, Huang Z, Xia H, Zhu X, Bian D, Sun F, Hou L, Wu C, Fan O R, Hu H, Zeng A*, Zhang L*, Sun Y E*, Wang C*, Zhang P*. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer, Nature Genetics, 2024, 57(1): 126-139.

3.Deng C^#, Li Z^#, Lu L^#, Zhang H, Chen R, Liu Y, Tong Y, Fan O R, Huang W, Sun Y E*, Yin F*, Cheng Y*. Sophisticated magneto-mechanical actuation promotes in situ stem cell assembly and chondrogenesis for treating osteoarthritis. ACS Nano, 2023, 17(21): 21690–21707.

4.Long J^#, Chen X^#, Shen Y^#, Lei Y^#, Mu L^#, Wang Z#, Xiang R, Gao W, Wang L, Wang L, Jiang J, Zhang W, Lu H, Dong Y, Ding Y, Zhu H, Hong D*, Sun Y E*, Hu J*, Liang A*. A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Cell Reports Medicine, 2023, 4(11):101286.

5.Wu D^#, Liu J^#, Liu J^#, Ge W^#, Wu S, Zeng C, Liang J, Liu K, Lin Q, Hong X*, Sun Y E*, Lu J*. Immune pathway activated in neurons triggers neural damage after stroke. Cell Reports, 2023, 42(1): 113368.

6.Hao F, Jia F, Hao P, Duan H, Wang Z, Fan Y, Zhao W, Gao Y, Fan O R, Xu F*, Yang Z*, Yi Sun Y E*, Li X*. Proper wiring of newborn neurons to control bladder function after complete spinal cord injury, Biomaterials, 2023, 292(1):121919.

7.Zhao C^#, Rao J^#, Duan H^#, Hao P^#, Shang J, Zhao W, Gao Y, Yang Z*, Sun Y E*, Li X*. Chronic spinal cord injury repair by NT3-Chitosan only occurs after clearance of the lesion scar. Signal Transduction and Targeted Therapy, 2022, 7(1):184.

8.Zhang Y, Li S, Jin P, Shang T, Sun R, Lu L, Guo K, Liu J, Tong Y, Wang J, Liu S, Wang C, Kang Y, Zhu w, Wang Q, Zhang X, Yin F, Sun Y E*, Cui L*. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis. Nature Communications, 2022, 13(1): 2447.

9.Li C^#, Wu Z^#, Zhou L^#, Shao J, Hu X, Xu W, Ren Y, Zhu X, Ge W, Zhang K, Liu J, Huang R, Yu J, Luo D, Yang x, Zhu W, Zhu R, Zheng C, Sun Y E*, Cheng L*. Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury. Signal Transduction and Targeted Therapy, 2022, 7(1): 65.

10.Liu J^#, Wang J^#, Xu J^#, Xia H^#, Wang Y^#, Zhang C, Chen W, Zhang H, Liu Q, Zhu R, Shi Y, Shen Z, Xing Z, Gao W, Zhou L, Shao J, Shi J, Yang X, Deng Y, Wu L, Lin Q, Zheng C, Zhu W, Wang C*, Sun Y E*, Liu Z*. Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVlD-19 vaccines. Cell Discovery, 2021, 7(1): 99.

11.Zhang C^#, Zhou L^#, Zhen Wang, Wenxia Gao, Wie Chen, Huina Zhang, Bo Jing, Xu Zhu, Lei Chen, Changhong Zheng, Kaiyan Shi, Li Wu, Liming Cheng, Zhang K*, Sun Y E*. Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values, Cell Death & Disease, 2021, 12(4): 357.

12.Lee C M^#, Zhou L^#, Liu J, Shi J, Geng Y, Wang J, Su X, Barad N, Wang J, Sun Y E*, Lin Q*. Single cell transcriptomic analysis revealed long-lasting adverse effects of prenatal tamoxifen administration on neurogenesis in prenatal and adult brains. PNAS, 2020, 117(32): 19578-19589.

13.Chen Y^#, Yu J^#, Niu Y#, Qin D^#, Liu H^#, Li G, Hu Y, Wang J, Lu Y, Kang Y, Jiang Y, Wu K, Li S, Wei J, He J, Wang J, Liu X, Luo Y, Si C, Bai R, Zhang K ,Liu J, Huang S, Chen Z, Wang S, Chen X, Bao x, Zhang Q, Li F, Geng R, Liang A, Shen D, Jiang T, Hu X, Ma Y, Ji W*, Sun Y E*. Modeling Rett syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys. Cell, 2017, 169(5): 945-955.

14.Luo Y^#, Coskun V^#, Liang A^#, Yu J^#, Cheng L^#, Ge W, Shi Z, Zhang K, Li C, Cui Y, Lin H, Luo D, Wang J, Lin C, Dai Z, Zhu H, Zhang J, Liu J, Liu H,Vellis J D, Horvath S, Sun Y E*, and Li S*. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell, 2015, 161(5): 1175-1186.

15.Liu H^#, Chen Y^#, Niu Y^#, Zhang K^#, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L,Zhou Q, Li S, Sun Y E*, Ji W*. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell, 2014, 14(3):323-328.

16.Wu H^#*, Coskun V, Tao J,Xie W, Ge W, Yoshikawa K, Li E, Zhang Y, Sun Y E*. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science, 2010, 329(5990):444-448.

17.Coskun V^#, Wu H, Blanchi B, Tsao S, Kim K,Zhao J, Biancotti J C, Hutnick L, Krueger Jr R C, Fan G, Vellis J D, Sun Y E*. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. PNAS, 2008, 105(3): 1026-1031.

18.He F^#, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, Vellis J D, Sun Y E*. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nature Neuroscience, 2005, 8(5): 616-625.

19.Martinowich K^#, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G*, Sun Y E*. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 2003, 302(5646):890-893.

20.Sun Y E^#, Nadal-Vicens M, Misono S, Lin M Z, Zubiaga A, Hua X, Fan G, Greenberg M E*. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell, 2001, 104(3):365-376.

1. 2025, ZL202410167514.X, A method to produce adult neural stem cells. Inventors: Yi Eve Sun, Xuejiao Yang, Wenmin Zhu.

2. 2024, CN202410863870.5, Protein IRF7 serves as a diagnostic biomarker for an autoimmune disease MCTD (mixed connective tissue disease). Inventors: Yi Eve Sun, Yanling Cui, Wenmin Zhu (granted).

3. 2024, CN202410863869.2, Protein STAT1 serves as a diagnostic biomarker for an autoimmune disease MCTD (mixed connective tissue disease). Inventors: Yi Eve Sun, Yanling Cui, Wenmin Zhu (granted).

4. 2023, ZL202210435069.1, Generation and application of a combinatorial biomaterial. Inventors: Changhong Zheng, Yi Eve Sun, Wenmin Zhu.

5. 2022, ZL202110103589.8, Application of ATF5 in screening drugs to treat mitochondrial gene 3243 point mutation-related disorders. Inventors: Congrong Wang, Yi Eve Sun, Yinan Zhang, Yuehua Wei, Fengwen Li, Zhixin Jiang.

6. 2022, ZL202110105370.1, Discoveries and Applications of microRNAs that target ATF5, Inventors: Congrong Wang, Yi Eve Sun, Yinan Zhang, Yuehua Wei, Fengwen Li, Lujia Li, Peng Liu.

7. 2020, ZL201710746062.0, Construction of a special cryo-preserve solution for human umbilical cord-derived mesenchymal stem cells, Inventors: Jie Liu, Yihui Zhu, Yi Eve Sun, Min Hu, Chijia Zeng, Jun Lu, Ting Xue, Caiqin Chen, Fangyuan Liao, Minghui Huang.

8. 2017, ZL201720214610.0, A special design of one-way interlock system to be implemented in cell production GMP laboratory, Inventors: Yi Eve Sun, Jie Liu, Aibing Liang, Yihui Zhu, Ting Xue, Caiqin Chen, Xiaochen Tang.

9. 2017, ZL201621376127.4, A special design of centrifuge tubes specifically for immune therapeutic testing, Inventors: Aibing Liang, Yi Eve Sun, Jie Liu, Ping Li, Wenjun Zhang, Junbang Wang, Xiaochen Tang, Yihui Zhu.

10. 2017, ZL201621377305.5, An apparatus for blood filtration to enrich specific cell type, Inventors: Jie Liu, Aibing Liang, Yi Eve Sun, Junbang Wang, Wenjun Zhang, Ping Li, Xiaochen Tang, Yihui Zhu.

11. 2016, ZL201521035591.2, A connector designed for multi-channel piped, Inventors: Jie Liu, Aibin Liang, Yi Eve Sun.

1. Zhang X, Sun Y E. (2025). Stem Cell Fundamentals and Regenerative Repair Technologies. Shanghai: Shanghai Jiao Tong University Press.

2. Tao J, Wu H, Sun Y E. (2009). Deciphering Rett Syndrome with Mouse Genetics, Epigenomics, and Human Neurons in Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders (Vol. 89, pp. 147–160). International Review of Neurobiology.